Kirsten Dunst
Mary Jane WatsonAlfred Molina
Doc Ock / Dr. Otto OctaviusTobey Maguire
Spider-Man / Peter ParkerRosemary Harris
May ParkerBruce Campbell
Snooty UsherElizabeth Banks
Dra. BrantBrent Briscoe
GunoierulSam Raimi
Student la Universitate (necreditat)Sam Raimi
Alvin Sargent
Steve Ditko
Kirsten Dunst
Mary Jane WatsonAlfred Molina
Doc Ock / Dr. Otto OctaviusTobey Maguire
Spider-Man / Peter ParkerRosemary Harris
May ParkerBruce Campbell
Snooty UsherElizabeth Banks
Dra. BrantBrent Briscoe
GunoierulSam Raimi
Student la Universitate (necreditat)Ted Raimi
HoffmanWillem Dafoe
Green Goblin / Norman OsbornJ.K. Simmons
J. Jonah JamesonDonna Murphy
Rosalie OctaviusJames Franco
Harry OsbornDaniel Dae Kim
RaymondCliff Robertson
Ben ParkerDaniel Gillies
John JamesonEmily Deschanel
ReceptioneraDan Hicks
Pasager in trenSpencer List
Baiatul care se juca pe scari (necreditat)Laura Ziskin
Avi Arad
Lorne Orleans
Danny Elfman
Bart Hendrickson
Bill Pope
Bob Murawski